Confirmation of a structural abnormity in the stroma of erythrocytes from paroxysmal nocturnal hemoglobinuria (PNH) after hemolysis in distilled water.
نویسندگان
چکیده
abniornusity of the erythrocytes.’ Ins 1951 i’sIatthes et al.2 described the patchy appearanice of electrois nsicrosoopic preparat-iomss of hensolyzed erythrocytes from onie case of PNH. Receistly, however, Douglas ansd Eaton2 were unsable to timid sinssilar chiansges. 1 h presenst report fully confirms the result of Mat-t-hes et sl.2 Its view of the theoretic ansd practical insportansce of this finsdinsg nsore available (tLses shsould be tested.
منابع مشابه
Intestinal perforation in a patient with paroxysmal nocturnal hemoglobinuria
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias.Acute abdominal pain is one of the PNH clinical manifestations due to venous thrombosis of intra-abdominal sites including hepatic, portal, mesenteric, and splenic veins.Eculizumaband allogeneic bone marrow transplantation (BMT) arethe only w...
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Ten consecutive patients with myeloysis. One patient had a positive sucrose fibrosis were examined for the following hemolysis test and low red cell ACHE. signs of PNH: Ham’s test, the sucrose The remaining patients had no signs of hemolysis test, low red cell acetylcholinPNH. In two of the patients, the PNH esterase (ACHE) activity and intrasigns disappeared after splenectomy. The vascular hem...
متن کاملThe properdin system and immunity. IV. The hemolysis of erythrocytes from patients with paroxysmal nocturnal hemoglobinuria.
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare chronic hemolytic anemia characterized by an acquired defect of the erythrocyte which renders it susceptible to hemolysis by normal human serum. Previous reports have indicated that magnesium and factors resembling the components of complement are required for the hemolysis in vitro of PNH erythrocytes by normal serum (1, 2). Recently a natura...
متن کاملLeukocyte antigen-antibody reaction and lysis of paroxysmal nocturnal hemoglobinuria erythrocytes.
T HE TRANSFUSION OF COMPATIBLE WHOLE BLOOD to patients suffering from paroxysmal nocturnal hemoglobinuria ( PNH ) is known to sometimes cause a hemolytic reaction. It has been suggested that leukocyte isoantibodies present in the patient’s serum through interaction with the donor’s leukocyte antigens are responsible for lysis of PNH red cells.’ As yet, it has not been clarified why this interac...
متن کاملSerum-red cell interactions at low ionic strength: erythrocyte complement coating and hemolysis of paroxysmal nocturnal hemoglobinuria cells.
Complement coating and hemolysis were observed when erythrocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH) were incubated in isotonic sucrose solution in the presence of small amounts of serum. Normal cells were likewise coated with complement components but did not hemolyze. Both normal and PNH erythrocytes reduced the hemolytic complement activity of the serum used in this ...
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عنوان ژورنال:
- Blood
دوره 11 8 شماره
صفحات -
تاریخ انتشار 1956